This prospective randomized trial demonstrates that integrating HDF into the EVLP circuit is feasible and safe during six hours of perfusion, without adverse effects on EVLP performance or short-term outcomes after lung transplantation. In the treatment group, electrolytes, lactate, and pH remained within physiological ranges, while transplant acceptance rates were higher, with comparable short-term outcomes after lung transplantation.
These findings suggest that restoring physiologic clearance mechanisms during EVLP may improve organ quality and help enable longer perfusion times.
The study was published in the Journal of Heart and Lung Transplantation:
https://doi.org/10.1016/j.healun.2026.04.009
Congratulations to Panja M. Boehm and the entire team on this outstanding achievement!